Novel Azalides Derived from Sixteen-Membered Macrolides
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چکیده
منابع مشابه
Pharmacodynamics of macrolides, azalides, and streptogramins: effect on extracellular pathogens.
The efficacy of macrolides against extracellular pathogens depends on extracellular levels of free drug and the organisms' patterns of susceptibility to the macrolides. The effect of macrolides against most bacteria is considered time-dependent. The size of inoculum affects erythromycin's activity against streptococci and, moreover, against staphylococci. The optimal effect is observed at a pH ...
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Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2007
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2007.55